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pentobarbital will minimize the extent or influence of itraconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can cut down panobinostat stages by ~